Review Article Skin wound healing modulation by macrophages
Mathieu P. Rodero, Kiarash Khosrotehrani
University of Queensland Centre for Clinical Research, Experimental Dermatology Group, Brisbane, Australia
Received July 5, 2010; accepted July 23, 2010; available online July 25, 2010
Abstract: Skin wound healing is a multi stage phenomenon that requires the activation, recruitment or activity of numerous cell types as keratinocytes, endothelial cells, fibroblast and inflammatory cells. Among the latter, macrophages appear to be central to this process. They colonize the wound at its very early stage and in addition to their protective immune role seem to organize the activity of other cell types at the following stages of the healing. Their benefit to this process is however controversial, as macrophages are described to promote the speed of healing but may also favour the fibrosis resulting from it in scars. Moreover wound healing defects are associated with abnormalities in the inflammatory phase. In this review, we summarise our knowledge on what are the Wound Associated Macrophages, and how they interact with the other cell types to control the reepithelialisation, angiogenesis and the extracellular matrix remodelling. We believe this knowledge may open new avenues for therapeutic intervention on skin wounds. (IJCEP1007002).
Address all correspondence to: Kiarash Khosrotehrani, MD, PhD University of Queensland Centre for Clinical Research Building 71/918 Royal Brisbane & Women's Hospital Campus Herston, QLD, 4029 Tel: +6173346 6077 Fax : +61733465598 E-mail: firstname.lastname@example.org