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Int J Clin Exp Pathol 2010;3(7):643-653

Review Article
Skin wound healing modulation by macrophages

Mathieu P. Rodero, Kiarash Khosrotehrani

University of Queensland Centre for Clinical Research, Experimental Dermatology Group, Brisbane, Australia

Received July 5, 2010; accepted July 23, 2010; available online July 25, 2010

Abstract: Skin wound healing is a multi stage phenomenon that requires the activation, recruitment or activity of numerous cell types as
keratinocytes, endothelial cells, fibroblast and inflammatory cells. Among the latter, macrophages appear to be central to this process. They
colonize the wound at its very early stage and in addition to their protective immune role seem to organize the activity of other cell types at the
following stages of the healing. Their benefit to this process is however controversial, as macrophages are described to promote the speed of
healing but may also favour the fibrosis resulting from it in scars. Moreover wound healing defects are associated with abnormalities in the
inflammatory phase. In this review, we summarise our knowledge on what are the Wound Associated Macrophages, and how they interact with
the other cell types to control the reepithelialisation, angiogenesis and the extracellular matrix remodelling. We believe this knowledge may
open new avenues for therapeutic intervention on skin wounds. (IJCEP1007002).

Keywords: Macrophage, skin wound, healing, inflammation, cytokines, growth factors, M1, alternatively activated

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Address all correspondence to:
Kiarash Khosrotehrani, MD, PhD
University of Queensland Centre for Clinical Research
Building 71/918
Royal Brisbane & Women's Hospital Campus
Herston, QLD, 4029
Tel: +6173346 6077
Fax : +61733465598
E-mail:
k.khosrotehrani@uq.edu.au