Case Report Carcinosarcoma of female urethra with melanocytic differentiation
Jun Liu, Hong Wu
Department of Pathology, University of Medicine and Dentistry of New Jersey/School of Osteopathic Medicine, West Cherry Hill, New Jersey, USA; Department of Pathology, Fox Chase Cancer Center, 333 Cottman Ave. Philadelphia, PA 19111, USA.
Received December 1, 2010; accepted January 24, 2011; Epub January 30, 2011; published February 15, 2011
Abstract: Carcinosarcoma arising from the female urethra is rare. We report an unusual case of urethral carcinosarcoma from a female patient with melanocytic differentiation. The tumor consists of a high-grade papillary serous carcinoma with psammoma bodies and a mesenchymal component with area of heterologous (cartilaginous) element. More interestingly, there are epithelioid tumor cells containing melanin pigment. On immunohistochemical stains, the epithelioid tumor cells are positive for S100, HMB45 and Mart-1, but negative for cytokeratin. This case represents an unusual carcinosarcoma with areas of melanocytic differentiation. Such rare tumors have been occasionally reported in the breast, uterus, kidney, and lung. These cases demonstrate the capacity of tumor cells to differentiate into divergent elements, supporting the concept of pluripotent tumor stem cells (IJCEP1012001).
Address all correspondence to: Dr. Jun Liu, Department of Pathology University of Medicine and Dentistry of New Jersey/ School of Osteopathic Medicine (UMDNJ/SOM) Kennedy Health System, 2201Chapel Ave, West Cherry Hill, NJ 08002, USA. Tel: 856-488-6422, Fax: 856-488-6624 E-mail: email@example.com