Department of Pathology and Laboratory Medicine and Department of Surgery, Temple University School of Medicine, Philadelphia, PA, USA.
Received December 27, 2010; accepted January 21, 2011; Epub January 30, 2011; published February 15, 2011
Abstract:Pleomorphic variant of lobular carcinoma is a recently described variant of invasive lobular carcinoma. It is reported to be positive for estrogen receptors and progesterone receptors and over express Her2/neu in most cases.We present here a case of invasive variant of pleomoprhic lobular carcinoma with coexisting classic and pleomorphic variants of lobular carcinoma in situ long with focal ductal carcinoma in situ. The immunohistochemical results on hormone receptors and high molecular weight cytokeratins in all the above components of the tumor are presented.The invasive tumor was negative for estrogen receptors, progesterone receptors and Her2/neu. Most foci of lobular carcinoma in situ showed morphogenic heterogeneity and a corresponding heterogenous staining for hormone receptors.The high molecular weight cytokeratins (CK5/6 and CK 903) were non contributory in establishing diagnosis. (IJCEP1012011).
Keywords: Invasive lobular carcinoma, variants, pleomorphic variant of lobular carcinoma, lobular carcinoma in situ, hormone receptors
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