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Int J Clin Exp Pathol 2011;4(2):200-205

Case Report
Invasive pleomorphic lobular carcinoma, negative for ER, PR and Her/2neu - a case report

Varsha Manucha, Natalya Khilko, Kathleen Reilly1, Xinmin Zhang

Department of Pathology and Laboratory Medicine and Department of Surgery, Temple University School of Medicine, Philadelphia, PA, USA.

Received December 27, 2010; accepted January 21, 2011; Epub January 30, 2011; published February 15, 2011

Abstract:Pleomorphic variant of lobular carcinoma is a recently described variant of invasive lobular carcinoma. It is reported to be positive for
estrogen receptors and progesterone receptors and over express Her2/neu in most cases.We present here a case of invasive variant of
pleomoprhic lobular carcinoma with coexisting classic and pleomorphic variants of lobular carcinoma in situ long with focal ductal carcinoma
in situ. The immunohistochemical results on hormone receptors and high molecular weight cytokeratins in all the above components of the
tumor are presented.The invasive tumor was negative for estrogen receptors, progesterone receptors and Her2/neu. Most foci of lobular
carcinoma in situ showed morphogenic heterogeneity and a corresponding heterogenous staining for hormone receptors.The high molecular
weight cytokeratins (CK5/6 and CK 903) were non contributory in establishing diagnosis. (IJCEP1012011).

Keywords: Invasive lobular carcinoma, variants, pleomorphic variant of lobular carcinoma, lobular carcinoma in situ, hormone receptors

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Address all correspondence to:
Dr. Varsha Manucha
Department of Pathology and Laboratory Medicine
Temple University School of Medicine
B339, Outpatient Bldg. 3401 N Broad Street
Philadelphia, PA 19140, USA.
Tel: (215) 707-6744, Fax: (215)-707-8132
E-mail:
varsha.manucha@tuhs.temple.edu