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Int J Clin Exp Pathol 2011;4(2):190-196

Case Report
Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma presenting as an
isolated nasopharyngeal mass: a case report and review of literature

Ke Li, Ann M.P. Tipps, Huan-You Wang

Department of Pathology, University of California San Diego Health Sciences, 3855 Health Sciences Drive, San Diego, CA 92093, USA.

Received December 28, 2010; accepted January 21, 2011; Epub January 23, 2010; published February 1, 2011

Abstract: Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma is a rare and distinct variant of diffuse large B-cell
lymphoma with characteristic morphologic, immunophenotypic, and cytogenetic features. We report a case of ALK-positive diffuse large B-cell
lymphoma in a 44-year-old male with progressively worsening unilateral nasal congestion and obstruction secondary to a nasopharyngeal
mass. Radiologically, the mass was showed to extend to orophanrynx from nasopharynx. Histologically, the tumor cells exhibited
plasmablastic morphology with expression of Bob-1, CD4, CD10, CD45, CD56, CD138, EMA, MUM1, Oct-2, and kappa immunoglobulin light
chain, but negative for CD20, CD30, CD79a, PAX-5, and lambda. More importantly, the neoplastic cells showed positive immunoreactivity for
ALK with exclusive cytoplasmic granular staining pattern. This case represented the second reported ALK-positive diffuse large B-cell
lymphoma in the nasopharyngeal region. (IJCEP1012012).

Keywords: Anaplastic lymphoma kinase (ALK), diffuse large B-cell lymphoma, nasopharyngeal mass, CD4, CD10

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Address all correspondence to:
Dr. Huan-You Wang
Department of Pathology
University of California San Diego Health Sciences
3855 Health Sciences Drive, La Jolla, CA 92093, USA.
Tel: 858-822-2538; Fax: 858-822-1415.
E-mail:
hywang2@ucsd.edu