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Int J Clin Exp Pathol 2011;4(3):315-321

Case Report
Metastatic balloon cell malignant melanoma: a case report and literature review

Lili Lee, Fang Zhou, Anthony Simms, Rosemary Wieczorek, Yanan Fang, Antonio Subietas-Mayol, Beverly Wang, Patricia Heller, Hongying
Huang, Zhiheng Pei, Iman Osman, Shane Meehan, Peng Lee

Department of Pathology, and Dermatology, New York University School of Medicine, New York Harbor Healthcare System, New York, NY and
Department of Pathology, State University of New York, Brooklyn, NY, USA.

Received February 14, accepted March 16, 2011; Epub March 22, 2011, published March 31, 2011

Abstract: A case of metastatic balloon cell malignant melanoma (BCMM) is presented.  The balloon melanoma cells (BMC) were absent in the
shave biopsy of the primary lesion and present as a minor component in the wide and deep excision.  A subsequent right neck lymph node
metastasis showed complete replacement of the lymph node by large, foamy cells.  Though the tumor was amelanocytic and Fontana-Masson
stain failed to reveal melanin, it stained positively for S-100, HMB-45, and Melan-A.  Ultrastructurally, the foamy cells were characterized by
cytoplasmic vacuolization and a lack of melanosomes.   The differential diagnosis of metastatic balloon cell malignant melanoma is broad,
and clinicopathologic correlation may play a critical role in achieving the correct diagnosis. (IJCEP1102002).

Keywords: Malignant melanoma, balloon cell, clear cell tumors

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Address all correspondence to:
Peng Lee MD, PhD
Department of Pathology and Urology
New York University School of Medicine,
New York Harbor Healthcare System
423 E. 23rd street, Room 6139N
New York, NY 10010
Phone: (212)951-3418
Fax: (212)951-6341
E-mail:
peng.lee@nyumc.org