Case Report Metastatic balloon cell malignant melanoma: a case report and literature review
Lili Lee, Fang Zhou, Anthony Simms, Rosemary Wieczorek, Yanan Fang, Antonio Subietas-Mayol, Beverly Wang, Patricia Heller, Hongying Huang, Zhiheng Pei, Iman Osman, Shane Meehan, Peng Lee
Department of Pathology, and Dermatology, New York University School of Medicine, New York Harbor Healthcare System, New York, NY and Department of Pathology, State University of New York, Brooklyn, NY, USA.
Received February 14, accepted March 16, 2011; Epub March 22, 2011, published March 31, 2011
Abstract: A case of metastatic balloon cell malignant melanoma (BCMM) is presented. The balloon melanoma cells (BMC) were absent in the shave biopsy of the primary lesion and present as a minor component in the wide and deep excision. A subsequent right neck lymph node metastasis showed complete replacement of the lymph node by large, foamy cells. Though the tumor was amelanocytic and Fontana-Masson stain failed to reveal melanin, it stained positively for S-100, HMB-45, and Melan-A. Ultrastructurally, the foamy cells were characterized by cytoplasmic vacuolization and a lack of melanosomes. The differential diagnosis of metastatic balloon cell malignant melanoma is broad, and clinicopathologic correlation may play a critical role in achieving the correct diagnosis. (IJCEP1102002).
Address all correspondence to: Peng Lee MD, PhD Department of Pathology and Urology New York University School of Medicine, New York Harbor Healthcare System 423 E. 23rd street, Room 6139N New York, NY 10010 Phone: (212)951-3418 Fax: (212)951-6341 E-mail: firstname.lastname@example.org