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Int J Clin Exp Pathol 2011;4(4):416-420

Case Report
Peripheral blood polyclonal plasmacytosis mimicking plasma cell leukemia in patients
with angioimmunoblastic T-cell lymphoma: Report of 3 cases and review of the literature

Arshad N. Ahsanuddin, Russell K. Brynes, Shiyong Li

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA; Department of Pathology, Keck
School of Medicine, University of Southern California, Los Angeles, CA, USA.

Received March 31, 2011; accepted April, 2011; Epub April, 2011, published May, 2011

Abstract: Angioimmunoblastic T-cell lymphoma (AITL) is a unique type of peripheral T-cell lymphoma. Patients with AITL may have occasional
reactive plasma cells present in the peripheral circulation.  Prominent peripheral blood polyclonal plasmacytosis mimicking plasma cell
leukemia, however, is distinctly uncommon. Here we describe 3 such cases from two large tertiary medical centers and discuss the role of
ancillary studies in the differential diagnosis of peripheral blood plasmacytosis. (IJCEP1103011).

Keywords: Angioimmunoblastic T-cell lymphoma, peripheral blood, plasmacytosis, flow cytometric immunophenotyping

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Address all correspondence to:
Shiyong Li, MD, PhD
Department of Pathology and Laboratory Medicine
Emory University Hospital
Room F143D, 1364 Clifton Rd NE
Atlanta, GA 30322.
Tel: 404-712-5456; Fax: 404-712-0819
E-mail:
sli2@emory.edu