Case Report Multicentric hepatic EBV-associated smooth muscle tumors in an AIDS patient: a case report, investigation of mTOR activation and review of the literature
Qi Shen, Wei Feng, Michael S. Long, Xiuzhen Duan, Siraya Jaijakul, Cesar A. Arias, Robert E. Brown, Bihong Zhao
Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, Houston TX, USA. North Cypress Medical Center, Cypress TX, USA; Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical School at Houston, Houston TX, USA.
Received April 10, 2011; accepted April 19, 2011; Epub April 23, 2011; published April 30, 2011
Abstract: Epstein-Barr virus (EBV) - associated smooth muscle tumors (EBV-SMT) are a rare, recently recognized distinct group of mesenchymal tumors that develop exclusively in patients with immunosuppression. It is believed that tumorigenesis is, at least in part, through the activation of the Akt/mammalian target of rapamycin (mTOR) signal pathway. We describe the clinicopathologic and immunohistochemical features of a multifocal hepatic EBV-SMT in a 34-year-old acquired immunodeficiency syndrome (AIDS) patient and investigate the activation status of the mTOR signal pathway in this tumor. In addition, we provide a review of the literature on the clinicopathologic findings of hepatic EBV-SMT in adult AIDS patients, and discuss their biologies and possible therapeutic strategies. (IJCEP1104008)
Address all correspondence to: Bihong Zhao, MD, PhD Department of Pathology & Laboratory Medicine The University of Texas Medical School at Houston 6431 Fannin Street, MSB-2.274 Houston TX, 77030, USA. Tel: (713) 500-5349; Fax: (713) 500-0733 E-mail: Bihong.Zhao@uth.tmc.edu