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Int J Clin Exp Pathol 2011;4(8):791-793

Case Report
Angiosarcoma of the mandibular gingiva

Tadashi Terada

Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.

Received August 12, 2011; accepted October 22, 2011; Epub November 3, 2011; published November 30, 2011

Abstract: Angiosarcoma of the oral cavity is extremely rare. A 77-year-old woman consulted to our hospital because of polypoid mass of the
mandibular gingival. Physical examination showed polypoid reddish mass measuring 1.5 x 1.5 x 1 cm in the mandibular gingival posterior to
the front tooth. Enucleation of the tumor was performed. Grossly, the tumor was not encapsulated. Histologically, the tumor consisted of
atypical spindle with hyperchromatic nuclei with nucleoli. Mitotic figures were scattered. Vasoformative channels were present in some areas.  
The surgical margins were positive. Immunohistochemically, the tumor cells were positive for factor VIII-related antigen, CD31, CD34, vimentin,
p53 protein, but negative for pancytokeratin (AE1/3 and CAM5.2), S100 protein, α-smooth muscle antigen, and desmin,  The Ki-67 labeling was
60%. A pathological diagnosis of angiosarcoma was made.  Radical operation is planned now.

Keywords: Oral cavity, angiosarcoma, histopathology

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Address all correspondence to:
Tadashi Terada, MD, PhD,
Department of Pathology
Shizuoka City Shimizu Hospital
Miyakami 1231, Shimizu-Ku, Shizuoka, 424-8636, Japan.
Tel: 81-54-336-1111, Fax: 81-54-336-1315
E-mail: piyo0111jp@yahoo.co.jp