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Int J Clin Exp Pathol 2011;4(7):722-726

Case Report
Translocation (5;11) in a conjunctival MALT lymphoma

Cecilia G. Clement, Venkateswara R. Potluri, John Gonzales, You-Wen Qian

Departments of Pathology and Ophtalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas, USA
Dynagene/LabCorp,Houston, Texas, USA.

Received August 15, 2011; accepted September 7, 2011; Epub September 30, 2011; Published October 31, 2011

Abstract: Lymphoma is the most frequent malignant tumor of the ocular adnexa with the most common histologic type being extranodal
marginal zone B-cell lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT lymphoma). Here we report a case of a 28-year old male
who presented with a left conjunctival mass of one year duration. A diagnosis of primary MALT lymphoma of the conjunctiva was made based
on morphologic and immunophenotypic studies. Chromosome analysis revealed a male karyotype with a translocation t(5;11)(q33;p11.2) as
the primary chromosomal abnormality, which, to the best of our knowledge,  is the first reported  translocation  in MALT lymphomas and ocular
MALT lymphomas as well. (IJCEP1108014).

Keywords: Translocation, MALT lymphoma, ocular, conjunctiva

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Address all correspondence to:
You-Wen Qian, MD, PhD
Department of Pathology
University of Texas Medical Branch at Galveston
5.152 McCullough Bldg, 301 University Blvd
Galveston, TX  77555, USA.
Tel: 409-772-2846 (O), Fax: 409-747-0628
E-mail: yoqian@utmb.edu