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Int J Clin Exp Pathol 2011;4(7):637-643
Role of leptin and its receptors in the pathogenesis of thyroid cancer
Shahab Uddin, Azhar R. Hussain, Omar S. Khan, Prashant P. Bavi, Khawla S. Al-Kuraya
Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Received August 17, 2011; accepted September 30, 2011; Epub October 3, 2011; Published October 31, 2011
Abstract: Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance.
Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth
and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or
Map kinases. In this review, current understanding of leptin’s role in the pathogenesis of thyroid cancer has been described. (IJCEP1108015).
Keywords: Leptin, leptin receptors, sinaling pathways, papillary thyroid carcinoma
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Address all correspondence to:
Shahab Uddin, PhD and Khawla S. Al-Kuraya, MD
Human Cancer Genomic Research,
King Faisal Specialist Hospital and Research Cancer
MBC#98-16, P.O. Box 3354, Riyadh 11211
Tel: (966)-1-205-5167; Fax: (966)-1-205-5170