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Int J Clin Exp Pathol 2011;4(7):713-717

Case Report
Extranodal NK/T-cell lymphoma, nasal type extensively involving the bone marrow

Sherif A. Rezk, Qin Huang

Department of Pathology & Laboratory Medicine, University of California, Irvine (UCI), Irvine, CA, USA; Department of Pathology, City of Hope
Medical Center, Duarte, CA, USA.

Received August 23, 2011; accepted September 17, 2011; Epub October 10, 2011; published October 31, 2011

Abstract: Extranodal NK/T-cell lymphoma, nasal type, is an aggressive EBV-associated lymphoma that mainly involves the nasal cavity but has
also been reported to involve other extranodal sites without nasal involvement. In contrast to aggressive NK cell leukemia (a marrow-based
aggressive leukemia of NK-cell origin); extensive bone marrow and blood involvement is extremely uncommon by nasal type NK/T lymphoma.
We report a patient with extranodal NK/T-cell lymphoma, nasal type that developed extensive bone marrow involvement during the course of her
disease with some overlapping features with aggressive NK-cell leukemia.

Keywords: Nasal NK cell lymphoma, aggressive NK cell leukemia, bone marrow

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Address all correspondence to:
Dr. Qin Huang
Department of Pathology
City of Hope National Medical Center
1500 East Duarte Road, Duarte
CA 91010, USA.
Tel. (626) 256-4673  Ext. 62037, Fax: (626) 301 8145
E-mail: qhuang@coh.org