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Int J Clin Exp Pathol 2011;4(7):667-673

Original Article
Claudins 10 and 18 are predominantly expressed in lung adenocarcinomas and in
tumours of nonsmokers

Heta Merikallio, Paavo Pääkkö, Terttu Harju, Ylermi Soini

Department of Internal Medicine, Respiratory Research Unit, Clinical Research Center, Oulu University Hospital, Oulu, Finland; Institute of
Clinical Medicine, Department of Internal Medicine, Respiratory Unit, Centre of Excellence in Research, University of Oulu, Oulu, Finland;
Department of Pathology, Oulu University Hospital, Oulu, Finland; Institute of Clinical Medicine, Department of Clinical Pathology and Forensic
Medicine, University of Eastern Finland, Kuopio, Finland; Cancer Center of Eastern Finland.

Received August 27, 2011; accepted September 15, 2011; Epub September 27, 2011; Published October 31, 2011

Abstract: Aims: We investigated the expression of claudins 18 and 10 in a large set of primary lung carcinomas. Methods and results:
Immunohistochemical expression of claudin 18 was seen in 12.7 % and claudin 10 in 12.5 % of lung carcinomas. Their expression
significantly associated with each other (p<0.001). The expression of claudin 18 and 10 was most prominent in lung adenocarcinomas which
displayed positivity in 21.2% and 23.4 % of cases. Female patients had more often claudin 18 and 10 positive tumors, also separately in
adenocarcinomas. Interestingly, claudin 10 (p=0.036) and claudin 18 (p=0.001) were more common in tumours of nonsmokers. In
adenocarcinomas claudin 18 predicted a better survival (p=0.032). In Cox multivariate analysis, claudin 18 had an independent prognostic
value (p=0.027).Conclusion: The results show that both claudins are most commonly expressed in lung adenocarcinomas and they are more
occasionally detected in other histological tumour types. Curiously, female patients and non-smokers express these claudins more commonly
suggesting that they may play a part in the carcinogenesis of tobacco unrelated carcinoma. Claudin 18 associated with a better survival in lung
adenocarcinoma and had an independent prognostic value and may thus be used in the evaluation of patient prognosis. (IJCEP1108020).

Keywords: Lung, carcinoma, claudin, smoker

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Address all correspondence to:
Dr. Ylermi Soini
Department of Pathology and Forensic Medicine
School of Medicine, Cancer Center of Eastern Finland
University of Eastern Finland
Po Box 1627, FI-70211 Kuopio, Finland.
E-mail: ylermi.soini@uef.fi