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Int J Clin Exp Pathol 2012;5(1):72-76

Case Report
Primary central nervous system B cell lymphoma with features intermediate between
diffuse large B cell lymphoma and Burkitt lymphoma

Liuyan Jiang, Zhimin Li, Laura E. Finn, David A. Personnet, Brandy Edenfield, James M. Foran, Kurt A. Jaeckle, Ronald Reimer, David M. Menke,
Rhett P. Ketterling, Han W. Tun

Department of Pathology, Mayo Clinic, Jacksonville, Florida, USA; Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA;
Department of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida, USA; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA;
Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic,
Rochester, Minnesota, USA.  

Received November 7, 2011; accepted November 22, 2011; Epub January 1, 2012; Published January 15, 2011

Abstract: B cell lymphoma with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (DLBCL/BL) is a new
lymphoma entity which is recognized in the current World Health Organization (WHO) classification (2008). We report a case of a primary
central nervous system lymphoma (PCNSL) with findings consistent with DLBCL/BL. It is characterized by a very aggressive clinical course,
and a widespread multifocal involvement of the CNS. Our case shows that a DLBCL/BL can manifest in the CNS alone without any systemic
involvement.
(IJCEP1111004).

Keywords: Lymphoma, central nervous system



Address all correspondence to:
Han W. Tun, MD
Department of Hematology and Oncology
Mayo Clinic Florida
4500 San Pablo Road
Jacksonville, Florida 32224 USA.
Tel: 904-953-6460 Fax: 904-953-2315
E-mail: Tun.Han@mayo.edu