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Int J Clin Exp Pathol 2012;5(4):356-358
Plasmacytoid adenocarcinoma of the lung
Departments of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.
Received November 11, 2011; accepted March 15, 2012; Epub April 16, 2012; Published May 30, 2012
Abstract: Plasmacytoid adenocarcinoma of the lung has not been reported. Herein reported is the first case of plasmacytoid adenocarcinoma
of the lung. A 68-year-old man presented with cough and sputum. X-P and CT demonstrated a large tumor (10 x 10 x 9 cm) in the right upper
lobe. CT-guided needle biopsy was performed. The biopsy showed plasmcytoid malignant cells. The malignant cells were small, had
eccentrically located nuclei, perinuclear halo, and basophilic cytoplasm. No mucins were observed by mucins stains. Immunohistochemical
study showed that the tumor cells were positive for pancytokeratin AE1/3, pancytokeratin CAM5.2, TTF-1, Ki-67 (labeling 70%), CA19-9, and p53.
They were negative for neuron specific enolase, CEA, CD45, CD68, chromogranin, synaptophysin, surfactant apoprotein A, CDX-2, κ-chain, λ-
chain, KIT, and PDGFRA. Since epithelial markers and adenocarcinoma markers were positive, the pathological diagnosis was plasmacytoid
adenocarcinoma of lung. The patient is now treated with chemotherapy. (IJCEP1111005).
Keywords: Lung, plasmacytoid adenocarcinoma, histopathology, immunohistochemistry
Address all correspondence to:
Dr. Tadashi Terada
Department of Pathology, Shizuoka City Shimizu Hospital
Miyakami 1231 Shimizu-Ku, Shizuoka 424-8636, Japan.
Tel: 81-54-336-1111; Fax: 81-54-336-1315