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Int J Clin Exp Pathol 2012;5(4):363-366

Case Report
Squamous cell carcinoma arising within verrucous carcinoma of the oral cavity: a case

Tadashi Terada

Departments of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.

Received November 11, 2011; accepted March 5, 2012; Epub April 16, 2012; Published May 30, 2012

Abstract: The author herein reports a case of squamous cell carcinoma (SCC) arising within verrucous carcinoma (VC) of the hard palate. An
84-year-old woman was admitted to our hospital complaining of oral discomfort. Oral examination revealed a pedunculated verrucous tumor
(15 x 15 mm) in the hard palate. A biopsy revealed verucous tumor. Resection of the lesion with wide margins was performed. Grossly, the
palate tumor was peduncutaed and verrucous, but a depressed area (8 x 7 mm) was recognized. Microscopically, the verruous ares showed
verrucous proliferation of squamous epithelium with little cellular atypia, and was interpreted as VC without invasion. The depressed lesion
was obvious SCC with invasion. There were direct transitions between the VC and SCC. Immunohistochemically, the VC and SCC tumor cells
were negative for human papilloma virus antigens. P53 protein was expressed in both VC and SCC, though the expression in SCC was much
more strong and broad than that in VC. The Ki-67 antigen was also expressed in the VC and SCC, and Ki-67 labeling index ranged was 12% in
VC and 64% in SCC. These findings indicate that SCC may arise within VC.

Keywords: Squamous cell carcinoma, verrucous carcinoma, Ki-67 antigen

Address all correspondence to:
Dr. Tadashi Terada
Department of Pathology, Shizuoka City Shimizu Hospital
Miyakami 1231 Shimizu-Ku, Shizuoka 424-8636, Japan.
Tel: 81-54-336-1111; Fax: 81-54-336-1315
E-mail: piyo0111jp@yahoo.co.jp