IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 2012;5(1):102-104

Case Report
Acquired hemophilia associated with bullous pemphigoid: a case report

Xiangning Qiu, Guiying Zhang, Rong Xiao, Jing Zhang, Ying Zhou, Ganqun Li, Kailin Yan, Qianjin Lu

Department of Dermatology, Second Xiangya Hospital, Central South University, No. 139, Renmin Road, Changsha, Hunan 410011, PR China.

Received November 15, 2011; accepted December 29, 2011; Epub January 5, 2011; published January 15, 2012

Abstract: The development of factor VIII inhibitors in non-hemophilic patients is rare and may occur in healthy individuals, mostly elderly and
women in postpartum period, and in patients with malignant neoplasia or autoimmune diseases, such as bullous pemphigoid. We described
the case of a 60-year-old female patient who developed bullous pemphigoid for 3 month and presented with bleeding tendency and hematoma
in the tongue. Therapy with methylprednisolone, cyclophosphamide, intravenous immunoglobulin and factor VIII reposition was instituted,
resulting in a remission of the bleeding and negativity for antibodies against factor VIII titers. We concluded that, despite its rarity, the presence
of acquired factor VIII inhibitors should be investigated when patients with autoimmune diseases develop bleeding manifestations.


Keywords: bullous pemphigoid, factor VIII inhibitor, acquired hemophilia

Address all correspondence to:
Rong Xiao MD, PhD
Professor and Vice-Chairman of Dermatology
Second Xiangya Hospital
Central South University
Changsha, Hunan 410011
Phone: 86-731-85295660
Fax: 86-731-85533525