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Int J Clin Exp Pathol 2012;5(1):89-95

Case Report
Rare case of a primary non-dural central nervous system low grade B-cell lymphoma
and literature review

Antonios Papanicolau-Sengos, Jessica Wang-Rodriguez, Huan-You Wang, Roland R. Lee, Anna Wong, Lawrence A. Hansen, Sepi Mahooti,
Hooman H. Rashidi:

Department of Pathology, University of California San Diego School of Medicine; Department of Pathology, University of California San Diego
School of Medicine & VA Medical Center, San Diego; Department of Radiology, University of California San Diego School of Medicine, San
Diego, CA, USA.

Received November 20, 2011; accepted December 7, 2011; Epub January 1, 2011; Published January 15, 2011

Abstract: We present a case of a 70-year-old HIV negative man with a five-year history of progressive dysnomia and new onset right extremity
numbness, dyssarthria, and blurry vision. On magnetic resonance imaging (MRI), an infiltrative enhancing tumor was noted. Follow up brain
biopsy results revealed a small lymphocytic infiltrate with scattered plasma cells in a predominantly perivascular growth pattern.
Flow-cytometric findings revealed a lambda monotypic B-cell population. The morphology and the flow cytometric findings were consistent with
involvement by a low grade B-cell lymphoma. Subsequent PET studies along with bone marrow biopsy and serum protein electrophoresis
results no evidence of systemic disease. The above findings are consistent with involvement by a non-dural extranodal marginal zone
lymphoma primary to the central nervous system (CNS). This is the first reported case of a primary CNS marginal zone lymphoma with flow
cytometric analysis. A review of literature on this rare entity is also included.
(IJCEP1111012).

Keywords: Primary Non-Dural Central Nervous System Low grade B-cell lymphoma, extranodal marginal zone lymphoma



Address all correspondence to:
Hooman Rashidi, M.D.
Department of Pathology
University of California San Diego School of Medicine and
Veteran Administration Medical Center of San Diego
9500 Gilman Drive # 9113
La Jolla, CA 92093-9113
Tel: (858)552-8585 ext 7623
Fax: 858-642-3918
E-mail: hhrashidi@ucsd.edu

Sepi Mahooti, M.D.
Department of Pathology
University of California San Diego School of Medicine and
Veteran Administration Medical Center of San Diego
9500 Gilman Drive # 9113
La Jolla, CA 92093-9113
Tel: (858)552-8585 ext 7741
Fax: 858-642-3918
E-mail: smahooti@ucsd.edu