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Int J Clin Exp Pathol 2012;5(2):140-142

Brief Communication
No evidence of endometriosis within serous and mucinous tumors of the ovary

Tadashi Terada

Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan

Received November 25, 2011; accepted January 31, 2012; Epub February 12, 2012; Published February 28, 2012

Abstract: Ovarian endometriosis can transform into malignant tumors. The author retrospectively examined HE slides of 112 serous tumors
and 75 mucinous tumors for the existence of ovarian endometriosis. When endometriosis is present within the tumors, the term
“endometriosis-derived tumor” was applied. When endometriosis is recognized adjacent to the tumor, the term “endometriosis-associated
tumor” was used. Of the 112 serous tumors (46 benign, 18 borderline, and 50 malignant), 4 (3.5%) (2 benign and 2 malignant) were
endometriosis-associated tumors. None was endometriosis-derived tumor. Of the 75 mucinous tumors (30 benign, 26 borderline, and 19
malignant), 4 (5%) (1 borderline and 3 benign) were endometriosis-associated tumors. No tumors showed endometriosis-derived tumors.
The data suggest that endometriosis does not transform into serous and mucous tumors. The author felt the limitation of retrospective survey,
because the limited numbers of slides (5 to 15) were obtained from each tumor. The author also felt that endometriosis can be difficult to
discern because of degenerative changes and other similar lesions such as fallopian tube, fimbria, inclusion cysts, rete ovarii, paraovarian
cyst, and Müllerian ducts remnants. Prospective study using whole ovarian examination is required.

Keywords: Ovary tumor, endometriosis, ovary serous tumor, ovary mucinous tumor, endometriosis-derived tumor

Address all correspondence to:
Dr. Tadashi Terada
Department of Pathology
Shizuoka City Shimizu Hospital
Miyakami 1231 Shimizu-Ku
Shizuoka 424-8636, Japan.
Tel: 81-54-336-1111; Fax: 81-54-336-1315
E-mail: piyo0111jp@yahoo.co.jp