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Int J Clin Exp Pathol 2012;5(1):77-82
Clinicopathologic study of endometrial dedifferentiated endometrioid adenocarcinoma: a
Yan Shen, Ying Wang, Jinsong Liu, Yixin Liu
Department of Pathology, Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin, China; Department of Pathology, The University of
Texas MD Anderson Cancer Center, Houston, TX, USA.
Received November 30, 2011; accepted December 20, 2012; Epub January 1, 2011; Published January 15, 2011
Abstract: In 2006, dedifferentiated endometrioid adenocarcinoma (undifferentiated carcinoma associated with low-grade endometrioid
carcinoma) of the uterus was first proposed. Dedifferentiated endometrioid carcinoma is part of the spectrum of undifferentiated carcinoma of
the endometrium which is a highly aggressive tumor even when the undifferentiated component represents only 20% of the entire neoplasm.
Therefore, accurate diagnosis and appropriate classification of this neoplasm are important in patient management. Lack of the recognition
may lead to misclassification of dedifferentiated endometrioid adenocarcinoma as a pure endometrioid adenocarcinoma which is less
aggressive. Only 4 papers have appeared in the literature so far on the topic of dedifferentiated endometrioid carcinoma. We report herein a
first case of endometrial dedifferentiated endometrioid carcinoma in a 51-year old woman in Chinese population. We performed
immunoperoxidase studies for 12 markers. Among them, cytokeratins, keratin 7, keratin 18, EMA, estrogen receptor (ER) and progesterone
receptor (PR), and vimentin show significantly differential expression between differentiated and undifferentiated area. (IJCEP1111016).
Keywords: Endometrium, dedifferentiated endometrioid adenocarcinoma, undifferentiated carcinoma, endometrioid adenocarcinoma
Address all correspondence to:
Yan Shen, MD
Department of Pathology
Tianjin Central Hospital of Gynecology and Obstetrics