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Int J Clin Exp Pathol 2012;5(1):105-109

Case Report
Lymphoepithelioma-like carcinoma of the colon

David Delaney, Runjan Chetty

Department of Cellular Pathology and Nuffield Department of Clinical Laboratory Science, Biomedical Research Centre Oxford, Oxford
University Hospitals Trust, University of Oxford, United Kingdom.

Received December 16, 2011; accepted December 29, 2011; Epub January 5, 2011; Published January 15, 2011

Abstract: An 85-year old female had a polypoid tumour in the sigmoid colon that histologically conformed to a lymphoepithelioma-like (LEL)
carcinoma.  The tumour was arranged in cords, chains, clusters and microalveoli of pleomorphic, irregular cells set within a dense
intratumoural lymphocytic stroma.  The tumour was EBV-negative and showed loss of MLH-1 and PMS-2 mismatch repair proteins.  The patient
did not fulfil the criteria for HNPCC. Only 5 other cases of primary colonic LEL carcinoma have been described previously and only one case
appears to have an unequivocal association with EBV.  In addition, one of the cases was encountered in a HNPCC patient. This is an unusual
morphologic variant of a microsatellite unstable tumour with a LEL pattern, not associated with EBV.

Keywords: Lymphoepithelioma-like carcinoma, medullary carcinoma, mismatch repair proteins, EBV, intratumoural lymphocytes,
microsatellite instability

Address all correspondence to:
Dr. Runjan Chetty
Department of Cellular Pathology, Level 1, Academic Centre
John Radcliffe Hospital
Headley Way, Headington
Oxford, OX3 9DU
United Kingdom.