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Int J Clin Exp Pathol 2012;5(3):203-209
Malignant tumors of the small intestine: A histopathologic study of 41 cases among 1,312
consecutive specimens of small intestine
Departments of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.
Received January 9, 2012; accepted February 23, 2012; Epub March 25, 2012; Published March 30, 2012
Abstract: There are few comprehensive studies of small intestinal malignancies. The author retrospectively reviewed 1,312 archival pathologic
specimens of the small intestine in the last 10 years in our pathologic laboratory in search for malignant tumors of the small intestine. There
were 22 cases (1.7%) of primary adenocarcinoma, 3 cases (0.2%) of primary squamous cell carcinoma, 6 cases (0.5%) of metastatic
carcinoma, 6 cases (0.5%) of malignant lymphoma, 3 cases (0.2%) of carcinoid tumor, and 1 case (0.08%) of gastrointestinal stromal tumor
(GIST). Of the 25 cases of primary adenocarcinoma and squamous cell carcinoma, 24 cases were located in the duodenum and 1 case in the
ileum. The 22 cases of adenocarcinoma were classified into 7 well differentiated, 7 moderately differentiated, and 8 poorly differentiated
adenocarcinomas. All the three squamous cell carcinomas were moderately differentiated ones with keratinization and intercellular bridges. In
the 25 cases of carcinoma, immunoreactive p53 protein was present in 23 cases, and the Ki-67 labeling ranged from 40% to 95% with a mean
of 76%. In the 6 cases of metastatic adenocarcinoma, the origin was ovary in 1 case, pancreas in 2 cases, gall bladder in 1 case, lung in 1
case, and colon in 1 case. In the 6 cases of lymphoma, 4 cases were diffuse large B-cell lymphomas and 2 cases were peripheral T-cell
lymphomas. In the 3 cases of carcinoid tumor, all were typical carcinoids and immunohistochemically positive for at least one of
neuroendocrine markers (chromogranin, synaptophysin, neuron specific enolase, and CD56). In the 1 case of GIST, the cell type is spindle and
GIST cells were immunohistochemically positive for KIT and CD34. The histological risk was intermediate. Forty-one cases of small intestinal
malignancies were reviewed histopathologically. (IJCEP1201002).
Keywords: Small intestine, carcinoma, adenocarcinoma, squamous cell carcinoma, histopathology
Address all correspondence to:
Dr. Tadashi Terada
Department of Pathology, Shizuoka City Shimizu Hospital
Miyakami 1231 Shimizu-Ku, Shizuoka 424-8636, Japan.
Tel: 81-54-336-1111; Fax: 81-54-336-1315