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Int J Clin Exp Pathol 2012;5(3):274-277
Ovarian cystic tumor composed of Brenner tumor and struma ovarii
Tadashi Terada, Kazuhiro Tateoka
Departments of Pathology and Gynecology, Shizuoka City Shimizu Hospital, Shizuoka, Japan
Received February 22, 2012; accepted March 11, 2012; Epub March 25, 2012; Published March 30, 2012
Abstract: Ovarian tumor composed only of Brenner tumor and struma ovarii is very rare; only 6 cases have been reported in the English
literature, to the best of the author’s knowledge. A 66-year-old woman underwent right oophorectomy because of torsion of right ovarian cyst.
Macroscopically, the ovarian cyst was hemorrhagic and red. Cystic content was hemorrhagic fluid. Microscopically, the cyst walls were
composed only of Brenner tumor (50% in area) and struma ovarii (50% in area). Hemorrhage and ischemic changes were seen. Other
elements were not recognized. No malignant transformation was noted. These two elements were separately present, and no mergers
between them were recognized. Immunohistochemically, the Brenner tumor element was positive for cytokeratins (AE1/3 and CAM5.2) and
Ki67 (labeling=3%), but negative for thyroglobulin, TTF-1, p53, CA125, and vimentin. The struma ovarii element was positive for cytokeratins
(AE1/3 and CAM5.2), thyroglobulin, TTF-1 and Ki67 (labeling=5%), but negative for p53, CA125 and vimentin. The findings suggests that there
were cases of ovarian cyst composed only of Brenner tumor and struma ovarii, that such a case may be monodermal mature cystic teratoma or
the Brenner tumor element was derived from surface epithelium in the preexisting struma ovarii, and that such a tumor manifest as cystic
Keywords: Brenner tumor, struma ovarii, ovarian cyst, torsion of ovarian cyst, histopathology, immunohistochemistry
Address all correspondence to:
Dr. Tadashi Terada
Department of Pathology, Shizuoka City Shimizu Hospital
Miyakami 1231 Shimizu-Ku, Shizuoka 424-8636, Japan.
Tel: 81-54-336-1111; Fax: 81-54-336-1315