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Int J Clin Exp Pathol 2012;5(7):707-709

Case Report
Papillary squamous cell carcinoma of the mandibular gingiva

Tadashi Terada

Departments of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan

Received March 13, 2012; Accepted July 4, 2012; Epub September 5, 2012; Published September 15, 2012

Abstract: Papillary squamous cell carcinoma (PSCC) has rarely been reported in the oral cavity. Herein reported is a case of PSCC in the
mandibular gum. A 70-year-old man consulted our hospital because of a papillary tumor in the left mandibular gum. Physical examination
revealed an exophytic papillary tumor of the left mandibular gum, and an excision of the tumor was performed. Grossly, the tumor was exophytic
and papillary, and measured 1 x 1 x 0.8 cm. Microscopically, the tumor showed exophytic papillary proliferation with fibrovascular cores and
consisted of atypical squamous epithelial cells. The tumor cells showed hyperchromasia, nuclear atypia, mitotic figures, apoptotic bodies,
cancer pearls, and individual keratinization. Mild stromal invasion was seen. Immunohistochemically, the tumor cells were positive for
pancytokeratin AE1/3, pancytokeratin CAM5.2, p63, p53, and Ki-67 (labeling index=40%), but negative for human papilloma virus (HPV). HPV in
situ hybridization revealed no signals. Therefore, PSCC was diagnosed. The lateral and vertical margins are negative for tumor cell. The
pathological diagnosis was PSCC. The patient was healthy and free from tumor three months after the operation. (IJCEP1203009).

Keywords: Papillary squamous cell carcinoma, oral cavity

Address all correspondence to:
Tadashi Terada, MD, PhD
Department of Pathology, Shizuoka City Shimizu Hospital
Miyakami 1231 Shimizu-Ku
Shizuoka 424-8636, Japan.
Tel: +81-54-336-1111; Fax: +81-54-334-1173
E-mail: piyo0111jp@yahoo.co.jp