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Int J Clin Exp Pathol 2012;5(6):592-595

Case Report
Concurrent Paget’s disease and basal cell carcinoma of the vulva: a case report

Maisoun Abdelbaqi, Rodney E Shackelford, Brian C Quigley, Ardeshir Hakam

Department of Anatomic Pathology, H Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA; Department of
Pathology and Laboratory Medicine, Tulane University School of Medicine 1430 Tulane Avenue, SL-79, New Orleans, LA 70112, USA

Received April 13, 2012; Accepted June 19, 2012; Epub July 25, 2012; Published August 15, 2012

Abstract: An 82-year-old Caucasian woman had a long-standing history of recurrent Paget’s disease of the right perianal region that was
documented by multiple skin biopsies. Histological examination of a skin biopsy from an erythematous raised right perianal area revealed
large rounded cells with ample pale staining cytoplasm scattered throughout the epidermis in multifocal nests and a flattened basal layer. A
second lesion showed tongues of basaloid cells with peripheral palisading in continuity with the undersurface of the epidermis at multiple
points. The individual tumor nests had cytoplasmic melanization and slit-like stromal separation. The tumor cells in the epidermis showed
positive immunoreactivity for carcinoembryonic antigen while the basaloid cells were negative. A diagnosis of combined vulvar Paget’s disease
and basal cell carcinoma of an infundibulocystic type was rendered. Concurrent involvement of the same area by Paget's disease and Basal
cell carcinoma (BCC) has been reported only once. Here we report a second case of BCC concurrent with vulvar Paget's disease.

Keywords: Basal cell carcinoma, infundibulocystic, biology, Paget’s disease, vulva, carcinoembryonic antigen

Address all correspondence to:
Dr. Ardeshir Hakam
Senior Faculty Member
Department of Anatomic Pathology
H Moffitt Cancer Center and Research Institute
Tampa, FL, USA.
Tel: 813-745-1874; Fax: 1-813-745-1708
E-mail: Ardeshir.Hakam@moffitt.org