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Int J Clin Exp Pathol 2012;5(5):422-427

Original Article
High expression level of BLCA-4 correlates with poor prognosis in human bladder cancer

Qian Zhao*, Wen-Hao Shen*, Zhi-Wen Chen, Zhan-Song Zhou, Hui-Xiang Ji

Urology Department, Kunming General Hospital of Chengdu Military Region. No. 212, Daguan RD, Kunming, 650032; Urology Department,
Southwest Hospital Affiliated to Third Military Medical University. *Contributed to this paper equally.

Received April 6, 2012; accepted May 11, 2012; Epub May 23, 2012; Published June 30, 2012

Abstract: Objectives: To evaluate the association between BLCA-4 tissue expression and patients' prognosis in bladder cancer (BC). Methods:
BLCA-4 expression was analyzed using immunohistochemical staining methods on tissue samples from a consecutive series of 325 BC
patients who underwent resections between 2000 and 2006. The correlation of BLCA-4 expression and patients’ clinicopathological
parameters was evaluated. Survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model. Results:
BLCA-4 was highly expressed in 54.8% of the BC patients. BLCA-4 overexpression was significantly associated with tumor grade (P<0.001),
and stage (P<0.001). Kaplan-Meier survival analysis showed that high expression level of BLCA-4 resulted in a significantly poor prognosis of
BC patients. Multivariate analysis revealed that the BLCA-4 expression level was an independent prognostic parameter for the overall survival
rate of BC patients. Conclusions: These findings provide evidence that high expression level of BLCA-4 serves as a poor prognostic biomarker
for BC. BLCA-4 may be a potential target of antiangiogenic therapy for BC.

Keywords: BLCA-4, bladder cancer, biomarker, prognosis, immunohistochemical analysis

Address all correspondence to:
Dr. Hui-Xiang Ji
Urology Department, Southwest Hospital
Third Military Medical University
No. 33, Gaotanyanzheng RD
Chongqing, 400038, China.
E-mail: huixiangji@yahoo.com.cn