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Int J Clin Exp Pathol 2012;5(9):924-927

Brief Communication
Endometrioid adenocarcinoma of the ovary arising in atypical endometriosis

Tadashi Terada

Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan

Received April 22, 2012; Accepted August 31, 2012; Epub October 20, 2012; Published October 30, 2012

Abstract: Ovarian endometriosis can transform into malignant tumors, and ovarian carcinomas relatively frequently contain foci of
endometriosis. In this study, the author reviewed 15 cases of endometrioid adenocarcinoma of the ovary in the last 15 years of our pathology
laboratory in search for the presence of endometriosis within the tumor. Six (40%) of the 15 endometrioid adenocarcinoma were found to have
endometriosis in the tumor. All of the endometriosis were atypical. The age of the 6 patients ranged from 44 year to 78 year with a median of 59
years. Grossly, the endometrial adenocarcinomas with endometriosis were characterized by unilocular cystic tumors in 5 cases and
multilocular cystic tumor in one case. Histologically, the grade of endometrioid carcinoma was grade I in 3 cases, grade II in 2 cases and grade
III in 1 case. Endometriosis was mixed with the tumors or was present adjacent to the tumor. The endometriosis was composed of a layer of
atypical epithelium (atypical endometriosis), and gradual merges between endometriosis and carcinoma were present in 3 cases. These
findings suggest that atypical endometriosis can transform into endometrioid carcinoma. (IJCEP1204012).

Keywords: Endometrioid adenocarcinoma, ovary, atypical endometriosis, transform

Address all correspondence to:
Dr. Tadashi Terada,
Department of Pathology, Shizuoka City Shimizu
Hospital, Miyakami 1231 Shimizu-Ku, Shizuoka
424-8636, Japan. Tel: 81-54-336-1111; Fax: 81-54-
336-1315; E-mail: piyo0111jp@yahoo.co.jp