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Int J Clin Exp Pathol 2012;5(5):472-478

Original Article
Malignant peritoneal mesothelioma presented as peritoneal adenocarcinoma or primary
ovarian cancer: Case series and review of the clinical and immunohistochemical features

Salih Taşkın, Yeliz Gümüş, Saba Kiremitçi, Korhan Kahraman, Ayşe Sertçelik, Fırat Ortaç

Departments of Obstetrics and Gynecology and Pathology, Ankara University School of Medicine, Ankara, Turkey

Received April 25, 2012; accepted May 14, 2012; Epub May 23, 2012; Published June 30, 2012

Abstract: Diffuse peritoneal malignant mesothelioma is a rare, progressive, and ultimately fatal disease and it can present as primary
peritoneal carcinoma or ovarian cancer. Differential diagnosis is important to establish appropriate management. In this article the clinical
presentation, immunuhistochemical and histopathological features of 8 cases of diffuse peritoneal malignant mesothelioma cases presented
as peritoneal carcinoma or ovarian cancer are evaluated. According to findings of all reported cases, we concluded that clinical distinction of
malignant mesothelioma from ovarian cancer or peritoneal adenocarcinoma is very difficult. Differential diagnosis is reliably achieved by
immune profile of the tumors with a systematic approach of both positive and negative mesothelioma markers. (IJCEP1204013)

Keywords: Peritoneal mesotheliomas, peritoneal adenocarcinoma, ovarian cancer

Address all correspondence to:
Dr. Salih Taşkın
Ankara Üniversitesi Tıp Fakültesi
Kadın Hastalıkları ve Doğum Anabilim Dalı, 06100 Cebeci
Ankara, Turkey.
Tel: +90 532 3925195; Fax: +90 312 3203553
E-mail: salihtaskin@yahoo.com