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Int J Clin Exp Pathol 2012;5(6):609-613

Case Report
Late recurrence of sigmoid carcinoma mimicking primary vulvar cancer: case report and
review of the literature

Emre Pabuccu, Egemen Tolunay, Evren Kocbulut, Salih Taskın, Fırat Ortac, Ayse Sertcelik, Aysegul Sasmaz, Berna Savas

Ankara University School of Medicine, Department of Obstetrics and Gynecology; Ankara University School of Medicine, Department of Pathology

Received May 31, 2012; Accepted July 11, 2012; Epub July 29, 2012; Published August 15, 2012

Abstract: Objective: To demonstrate a unique case report about late and isolated vulvar metastasis of sigmoid adeno-carcinoma with review of
the literature. Material-method: 57 year old postmenopausal patient with prior sigmoid colon cancer was admitted with isolated vulvar mass.
Immunohistochemistry (IHC) and KRAS gen mutation analysis following surgery were performed to discriminate the metastasis from a vulvar
primary malignancy. Further imaging techniques were also performed to exclude additional tumours. Results: Immunohistochemistry (IHC)
and KRAS gene mutation analysis revealed  isolated metastasis of the colonic adeno-carcinoma in the vulva. Conclusion: Isolated and late
occurring vulvar metastasis of colonic origin is very unusual. Careful evaluation is mandatory and IHC is useful for such cases.

Keywords: Colon, immunohistochemistry, metastasis, sigmoid, vulva

Address all correspondence to:
Ankara Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı
06100 Cebeci, Ankara, Turkey.
Tel: +90 3125956914
E-mail: pabuccu@hotmail.com