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Int J Clin Exp Pathol 2012;5(8):762-769

Original Article
Primary peritoneal serous carcinoma: a clinicopathological and immunohistochemical
study of six cases

Teng Hou, Dongxia Liang, Jiehua He, Xu Chen, Yanna Zhang

State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, GD 510060, China; Department of
Urology, The First Affiliated Hospital Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, GD 510080, China

Received July 14, 2012; Accepted August 21, 2012; Epub October 1, 2012; Published October 15, 2012

Abstract: Aims: Primary peritoneal serous carcinoma (PPSC) is an unusual neoplasm that has not been properly characterized. To better
define the clinicopathological and immunohistochemical features of PPSC, we present 6 such cases. Methods: The 6 patients consisted of
one man and 5 women, ranging in age from 45 and 75 years. None of the patients had any history or clinical evidence of tumor elsewhere. The
immunohistochemical profile was examined using antibodies against β-catenin, E-cadherin, wnt5a, EGFR, VEGF, vimentin, Ki67, and P53.
Results: Of all the 6 PPSC cases, 5 cases presented stage IIIC and 1 case presented stage IV. Microscopically, 5 cases were poorly
differentiated and 1 was moderately differentiated. All cases showed positive staining for β-catenin, E-cadherin, vimentin, VEGF, P53, and Ki67,
4 cases expressed EGFR, and all cases were consistently negative for wnt5a. Conclusions: We described 6 cases of PPSC with
clinicopathological and immunohistochemical features. The findings provide basic knowledge of PPSC. (IJCEP1207009).

Keywords: Primary peritoneal serous carcinoma, epithelial ovarian cancer, serous carcinoma

Address all correspondence to:
Dr. Yanna Zhang, State Key Laboratory of Oncology in South China, 651 E Dongfeng Ave, Guangzhou, GD 510060, China. Tel: 8600
18718908165; Fax: 8600 2087343014; E-mail: zhangyn@sysucc.org.cn