IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 2012;5(8):830-833

Case Report
Epulis-like gingival angiosarcoma of the mandible: a case report

Tomoki Sumida, Ryuichi Murase, Yohei Fujita, Akiko Ishikawa, Hiroyuki Hamakawa

Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon-city, 791-0295, Ehime
Japan

Received July 16, 2012; Accepted September 5, 2012; Epub October 1, 2012; Published October 15, 2012

Abstract: A 55-year-old woman consulted our hospital for an epulis-like small mass in the anterior region of the mandible. A biopsy of the
tumor was performed. Histological analysis showed that the tumor consisted of spindleshaped and polygonal cells with hyperchromatic nuclei,
and intracytoplasmic vacuoles and mitotic figures were scattered. Immunohistochemical staining revealed that the tumor cells were positive for
factor VIII-related antigen, CD31, αSMA, and vimentin, but negative for pancytokeratins, S100 protein, neuron-specific enolase, and CD56. The
Ki-67 labeling index was more than 50%. Based on these findings, a final pathological diagnosis of angiosarcoma was made. The tumor did
not invade into the surrounding tissue. The operation was performed with about a 20-mm surgical margin that was negative for tumor invasion.
After a 4-year follow-up, no metastatic lesions were found, and the primary site was covered with a partial denture. (IJCEP1207011).

Keywords: Gingival angiosarcoma, mandible, gingiva, epulis-like shape, immunohistochemistry

Address all correspondence to:
Dr. Tomoki Sumida, Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon-city,
Ehime, 791-0295, Japan. Phone: +81 89 960 5393; Fax: +81 89 960 5396; E-mail: tomoki@m.ehime-u.ac.jp