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Int J Clin Exp Pathol 2012;5(7):720-725
Juvenile xanthogranuloma developing after treatment of Langerhans cell histiocytosis:
case report and literature review
Johanna D Strehl, Klaus-Daniel Stachel, Arndt Hartmann, Abbas Agaimy
Institute of Pathology and University Children’s Hospital, Erlangen, Germany
Received July 23 2012, Accepted Augest 4 2012, Epub September 5, 2012; Published September 15, 2012
Abstract: The synchronous or metachronous development of Langerhans cell histiocytosis and non-Langerhans cell histiocytosis in the same
patient is rare. To date, only seven cases of xanthogranulomas developing in young patients with a history of Langerhans cell histiocytosis and
systemic therapy have been reported in the literature. As of yet, the pathogenesis and the clinical significance of this phenomenon are unclear.
We report the case of a 3 year old boy who developed juvenile Xanthogranulomas on the forehead and right upper eye lid 1.5 years after
systemic therapy for monosystemic Langerhans cell histiocytosis of the bone and complete disease remission. (IJCEP1207020).
Keywords: Langerhans cell histiocytosis, juvenile xanthogranuloma, synchronous, metachronous, coincidence
Address all correspondence to:
Abbas Agaimy, MD
Pathologisches Institut, Krankenhausstrasse 8-10,
91054 Erlangen, Germany.
Tel: +49-(0) 9131 8522288 Fax: +49-(0) 9131 85 24745