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Int J Clin Exp Pathol 2012;5(8):777-786

Original Article
Early impaired β-cell function in chinese women with polycystic ovary syndrome

Tao Tao, Shengxian Li, Aimin Zhao, Xiuyin Mao, Wei Liu

Department of Internal Medicine Renji Hospital, Division of Endocrinology and Metabolism, Shanghai Jiaotong

University School of Medicine, 1630 Dongfang Road, Pudong, Shanghai, 200127, China; 2Department of Obstetrics and Gynecology, Division
of Reproductive Endocrinology and Infertility, Renji Hospital, Shanghai Jiaotong University School of Medicine, 1630 Dongfang Road, Pudong,
Shanghai, 200127, China. *These authors contributed equally to this paper.

Received July 24, 2012; Accepted September 6, 2012; Epub October 1, 2012; Published October 15, 2012

Abstract: Background: The pathogenic factors that account for the development of diabetes condition in Chinese women with polycystic ovary
syndrome (PCOS) remain elusive. Aim: To clarify the pathogenic features by evaluating the levels of insulin sensitivity and β cell function in
these women with PCOS, either separately or by using of a disposition indexes (DIs). Methods: Cross-sectional study involving 137 Chinese
women with PCOS and 123 normal women were examined by anthropometry, lipid profile, sex hormone, high-sensitivity C reactive protein, oral
glucose tolerance tests and insulin tolerance tests. Results: After controlling for BMI status, the Matsuda Index was significantly lower in
women with PCOS in comparison to those of normal women (p<0.000). The early phase of insulin secretion (insulinogenic index) remained
significantly lower in lean women with PCOS(LP) than those of both lean and obese women of control group (p=0.007, and p = 0.01,
respectively). The mean HOMA-F values were significantly lower (p =0.045) in obese women with PCOS (OP) than those of BMI-matched
women. Further, all DIs derived from non-fasting state indexes in women with PCOS were significantly lower than those of BMI-matched control
women (p<0.001 for all). Lastly, DIs derived from fasting states indexes in OP were significantly lower than those of LP. Conclusion: Early
impaired β cell function was detected in both LP and OP. However, more serious primary defect in insulin action was detected in LP compared
to OP. These findings imply that early screening and intervention for PCOS would be therapeutic for Chinese women. (IJCEP1207021).

Keywords: Polycystic ovary syndrome, insulin resistance, early phase secretion of insulin

Address all correspondence to:
Dr. Wei Liu, Division of Endocrinology and Metabolism, Department of Internal Medicine Renji Hospital, Shanghai Jiaotong University School of
Medicine, 1630 Dongfang Road, Pudong, Shanghai, 200127, China. Tel: 86-21- 68383083; Fax: 86-21-68383523; E-mail: sue_liuwei@163.
com