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Int J Clin Exp Pathol 2013;6(1):105-109

Case Report
Infectious mononucleosis mimicking malignant T-cell lymphoma in the nasopharynx: a
case report and review of the literature

Hong-Lin He, Ming-Chung Wang, Wan-Ting Huang

Department of Pathology and Department of Hematology and Oncology, Kaohsiung Chang Gung Memorial Hospital
and Chang Gung University College of Medicine, Kaohsiung, Taiwan

Received August 14, 2012; Accepted October 27, 2012; Epub November 20, 2012; Published January 1, 2013

Abstract: Infectious mononucleosis (IM) is Epstein-Barr virus-associated and self-limited lymphoproliferative disorder. The histopathologic
features of the nasopharynx in IM are rarely described. In this report, we described a patient of IM with atypical T-cell proliferation in the
nasopharynx. In-situ hybridization for EBV-encoded RNA with immunostaining against CD20 was used for evaluation of EBV infection. The
histopathologic features of IM could mimic malignant T-cell lymphoma. It should be differentiate reactive T-cell lymphoproliferation from
malignant lymphoma in the nasopharynx. (IJCP1208012).

Keywords: Infectious mononucleosis, IM, EBV, lymphoma

Address all correspondence to:
Dr. Wan-Ting Huang
Department of Pathology, Kaohsiung Medical Center
Chang Gung Memorial Hospital
123, Ta-pei Road, Niao-Sung Hsiang, Kaohsiung County, Taiwan.
Tel: 886-7-7317123 ext. 3067; Fax: 886-7-7333198;
E-mail: huangminnie@cgmh.org.tw