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Int J Clin Exp Pathol 2012;5(8):726-738

Review Article
The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA
damage repair and its implication in tumorigenesis

Yaqin Tu, Cai Chen, Junru Pan, Junfa Xu, Zhi-Guang Zhou, Cong-Yi Wang

The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang
Ave., Wuhan 430030; The Department of Clinical Immunology, Guangdong Medical College, 1 Xincheng Ave. Dongguan, 523808; 3Diabetes
Center, the Second Xiangya Hospital and Key Laboratory of Diabetes Immunology, Central South University, Changsha, China; The Center for
Biotechnology & Genomic Medicine, Georgia Health Sciences University, 1120 15th Street, CA4098, Augusta, GA 30912, USA. *These
authors contributed equally to this work.

Received August 21, 2012; Accepted September 11, 2012; Epub October 1, 2012; Published October 15, 2012

Abstract: Accumulated evidence supports that the ubiquitin proteasome pathway (UPP) plays a crucial role in protein metabolism implicated in
the regulation of many biological processes such as cell cycle control, DNA damage response, apoptosis, and so on. Therefore, alterations for
the ubiquitin proteasome signaling or functional impairments for the ubiquitin proteasome components are involved in the etiology of many
diseases, particularly in cancer development. In this minireview, we first give a brief outline for the ubiquitin proteasome pathway, we then
discuss with focus for the ubiquitin proteasome pathway in the regulation of cell cycle control and DNA damage response, the relevance for the
altered regulation of these signaling pathways in tumorigenesis is also reviewed. We finally assess and summarize the advancement for
targeting the ubiquitin proteasome pathway in cancer therapy. A better understanding of the biological functions underlying ubiquitin regulatory
mechanisms would provide us a wider prospective on cancer treatment. (IJCEP1208018).

Keywords: Ubiquitin proteasome pathway, ubiquitination, cell cycle, DNA damage response, tumorigenesis


Address all correspondence to:
Dr. Cong-Yi Wang, The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and
Technology, 1095 Jiefang Ave., Wuhan 430030, China. Tel: 86-27-8366-3487, E-mail: cwang@georgiahealth.edu.

Dr. Zhi-Guang Zhou, Diabetes Center, the Second Xiangya Hospital and Key Laboratory of Diabetes Immunology, Central South University,
Changsha, China. Tel: 86-731-8529-4018. E-mail: zhouzg@hotmail.com