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Int J Clin Exp Pathol 2012;5(9):874-881

Review Article
GP73 expression and its significance in the diagnosis of hepatocellular carcinoma: a

Ming-Chen Ba, Hui Long, Yun-Qiang Tang, Shu-Zhong Cui

Department of Hepatobiliary Tumor Surgery, Cancer Hospital of Guangzhou Medical College, Guangzhou 510095, PR China; Department of
Pharmacy, Guangzhou Dermatology Institute, Guangzhou 510095, PR China.

Received August 26, 2012; Accepted September 29, 2012; Epub October 20, 2012; Published October 30, 2012

Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and its incidence has been increasing worldwide.
Serum alpha-fetoprotein (AFP) levels and abdominal ultrasound have been widely used for diagnosis as well as surveillance of HCC.
However, the sensitivity and specificity of both AFP levels and ultrasound for HCC surveillance have some shortcomings, particularly in the early
stages of the disease. Golgi protein-73 (GP73) is a type II Golgi-localized integral membrane protein that is normally expressed in epithelial
cells of many human tissues. It is essential for human survival, and might have multiple roles for GP73 in epithelial cell function such as in the
kidney and liver. However, details of its biochemical function and regulation of GP73 expression are unknown at present. GP73 expression is
upregulated in serum samples from patients with liver disease, with expression being highest in HCC. Therefore, it may be useful as a new
serum marker for detection of HCC in at high-risk population. But, this hypothesis needs to be proven in large cohorts. (IJCEP1208023).

Keywords: Hepatocellular carcinoma, liver disease, alpha-fetoprotein, golgi protein73, tumor marker

Address all correspondence to:
Dr. Ming-chen Ba
Department of Hepatobiliary Tumor Surgery
Cancer Hospital of Guangzhou Medical College
Guangzhou 510095, P.R. China.
Tel: +86-13825017156; Fax: +86-20-83509106
E-mail: bamingchen@126.com;

Dr. Hui Long, Department of Pharmacy
Guangzhou Dermatology Institute
Guangzhou 510095, PR China.
Tel: +86-13535448232; Fax: +86-20-83489984
E-mail: 798587414@qq.com