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Int J Clin Exp Pathol 2013;6(1):97-99
Vascular leiomyoma of the lung arising from pulmonary artery
Departments of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan
Received September 29, 2012; Accepted November 1, 2012; Epub November 20, 2012; Published January 1, 2013
Abstract: Leiomyoma of the lung is extremely rare. The entity is not described in WHO blue book. Less than 100cases of leiomyoma of the
lung have been reported in the literature. However, vascular leiomyoma has not beenreported in the literature, to the author’s best knowledge.
Herein reported is the first case of vascular leiomyomaof the lung arising from smooth muscles of the pulmonary artery. A 62-year-old woman
(non-smoker) was found tohave a small tumor in the upper lobe in the right lung in routine check. Imaging modalities including CT
demonstratedno metastatic lesions. Although clinical cytology and biopsy revealed no malignant cell, right upper lobectomywas performed
under the clinical diagnosis of lung carcinoma. Grossly, a white tumor of 1 x 0.8 cm was recognizedin the lung. Microscopically, the tumor was
connected to the pulmonary arteries. The tumor was composed ofmature smooth muscles. Small pulmonary arteries are embedded in the
tumor. No lymphatics were seen. Immunohistochemically,the tumor cells were poisitive for alpha-smooth muscle actin, vimentin and Ki-67
(labeling2%). However, they were negative for cytokeratin (CK) AE1/3, CK CAM5.2, desmin, S100 protein, p53, CD34, KIT,HMB45, estrogen
receptor, progesterone receptor, and myoglobin. A pathological diagnosis of primary vascularleiomyoma arising from the smooth muscle of
pulmonary artery was made. The patient is now free from tumor, andis now alive 10 year after the operation. (IJCEP1209030).
Keywords: Lung, leiomyoma, pulmonary artery, immunohistochemistry
Address all correspondence to:
Dr. Tadashi Terada
Department of Pathology
Shizuoka City Shimizu Hospital
Miyakami 1231 Shimizu-Ku
Shizuoka 424-8636, Japan.
Tel: 81-54-336-1111; Fax: 81-54-336-1315