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Int J Clin Exp Pathol 2013;6(1):49-54

Original Article
Correlation of monoclonal and polyclonal somatostatin receptor 5 antibodies in
pancreatic neuroendocrine tumors

Daniel Kaemmerer, Amelie Lupp, Luisa Peter, Elke Fischer, Stefan Schulz, Günter Klöppel, Merten Hommann

Department of General and Visceral Surgery, Zentralklinik Bad Berka, Bad Berka, Germany; Department of Pharmacology and Toxicology, Jena
University Hospital, Friedrich-Schiller University, Jena, Germany; Department of Pathology, Technical University of München, 81675 München,

Received October 22, 2012; Accepted November 11, 2012; Epub November 20, 2012; Published January 1, 2013

Abstract: Aims: To evaluate the frequency of somatostatin-receptor 5 (SSTR 5) in pancreatic neuroendocrine tumors by using monoclonal and
polyclonal antibodies. Material and Method: we analyzed 66 proven pancreatic neuroendocrine tumors immunohistochemically with
monoclonal (clone UMB-4) and polyclonal SSTR 5-antibodies. Immunoreactive score (IRS) and DAKO-score Her2/neu were evaluated.
Results: Immunohistochemistry analysis demonstrated for the IRS a significant higher staining of all specimen using the monoclonal
antibodies ( IRS SSTR5 poly vs IRS SSTR 5 mono; 20.0% vs 30.3% p < 0.001) by a correlation of 0.21; p = 0.04. For the HER2 score there was
also a significant higher staining in the monoclonal group (Her2 SSTR 5 poly vs Her2 SSTR 5 mono; 21.5% vs 28.8% p < 0.001) by a
correlation of 0.20; p = 0.08. Conclusion: Both antibodies are useful in staining of SSTR, although UMB-4 demonstrated a 10% higher SSTR 5
staining. Due to the previous underestimated expression rate of SSTR 5, current standards in diagnostics and therapy should be reconsidered.
The increasing usage of long-acting pansomatostatin receptor analogues will rise the adverse effects connected to SSTR5 binding.

Keywords: Somatostatin, pancreatic tumor, neuroendocrine tumor, monoclonal antibody

Address all correspondence to:
Dr. Rong Xiao
Department of Dermatovenereology
Second Xiangya Hospital, Central South University
No. 139, Renmin Road, Changsha, Hunan 410011, PR china.
Tel: +86 731 85295660; Fax: +86 731 85533525
E-mail address: xiaorong65@yahoo.com.cn