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Int J Clin Exp Pathol 2013;6(5):932-938

Original Article
Adenoid cystic carcinoma of the oral cavity: immunohistochemical study of four cases

Tadashi Terada

Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan

Received November 23, 2012; Accepted March 27, 2013; Epub April 15, 2013; Published May 1, 2013

Abstract: Adenoid cystic carcinoma (ACC) in the oral cavity is rare, and no immunohistochemical studies of ACC in the oral cavity have been
performed. This report describes the immunohistochemical study of four ACCs of the oral cavity. The male to female ratio was 1:3. The age
was 43, 51, 59 and 64 years. The location was tongue (n=2), buccal mucosa (n=1), and gingiva (n=1). Histochemically, all ACCs were positive
for neutral, carboxylated and sulfated mucins. Immunohistochemically, ACC was consistently positive for cytokeratin (CK) AE1/3, CK 34βE12,
CK5/6, CK7, CK14, CK18, p63, CA19-9, c-KIT (CD117), PDGFRA, MUC1, and Ki-67 (labeling index: 5%, 15%, 20% and 40%). ACC was
consistently negative for CK8, CK20, desmin, S100 protein, CD34, chromogranin, MUC2, MUC5AC and MUC6. Some ACCs were positive for
CK CAM5.2 (3/4), CK19 (1/4), EMA (2/4), CEA (2/4), vimentin (3/4), α-smooth muscle actin (2/4), p53 (2/4), CD10 (2/4), and synaptophysin (1/4).
These results may provide basic knowledge of ACC of the oral cavity. (IJCEP1211024)

Keywords: Adenoid cystic carcinoma, oral cavity, immunohistochemistry

Address correspondence to: Dr. Tadashi Terada, Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231, Shimizu-Ku,
Shizuoka 424-8636, Japan. Phone: 81-54-336-1111; Fax: 81-54-336-1315; E-mail: piyo0111jp@yahoo.co.jp