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Int J Clin Exp Pathol 2013;6(3):510-515

Original Article
Correlation analysis on central lymph node metastasis in 276 pa-tients with cN0 papillary
thyroid carcinoma

Wendong Wang, Jialei Gu, Jinbiao Shang, Kejing Wang

Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China

Received November 29, 2012; Accepted January 3, 2013; Epub February 15, 2013; Published March 1, 2013

Abstract: Objective: To explore the relationship between sex, age, capsule invasion, tumor size, tumor location, number and central lymph
node metastasis. Methods: Correlation analysis was conducted on clinical data of 276 patients with cN0 papillary thyroid carcinoma who
underwent central lymph node dissection. Results: There was significant difference between patients less than 45 years old and greater than
or equal 45 years old (P<0.05), between patients with capsule invasion and without capsule invasion (P<0.05); there were significant
differences in the central lymph node metastasis rate between group with Φ≤0.5cm as well as Φ>2cm and the other three groups (P<0.05),
and there was significant difference between upper pole group and middle/lower pole group (P<0.05) while no significant difference was found
between middle pole and lower pole (P>0.05); there was also no significant difference in the central lymph node metastasis rate between
groups with 1 tumor and greater as well as equal 2 (P>0.05). Conclusion: We considered the tumor located in middle and lower pole, Φ>0.5cm
of tumor size, less than 45 years old and the present of capsule invasion were high risk factors of central lymph node metastasis, so we
strongly recommend performing central lymph node dissection in synchronization. (IJCEP1211043).

Keywords: Hyroid tumors, papillary carcinoma, lymph node metastasis, neck dissection

Address correspondence to: Dr. Jinbiao Shang, Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
E-mail: 11018010@zju.edu.cn