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Int J Clin Exp Pathol 2013;6(5):990-993

Case Report
Primary pure squamous cell carcinoma of the endometrium: a case report

Tadashi Terada, Kazuhiro Tateoka

Department of Pathology and Gynecology, Shizuoka City Shimizu Hospital, Shizuoka, Japan

Received December 4, 2012; Accepted March 3, 2013; Epub April 15, 2013; Published May 1, 2013

Abstract: Because primary pure squamous cell carcinoma (SCC) of the endometrium is very rare and its frequency is unknown, the author
reviewed 142 archival hysterectomy specimens of endometrial cancers. As the results, one case of primary pure SCC was found. Thus, the
frequency of SCC of the endometrium was 0.7% of all endometrial malignancies in our institution. The patient was a 72-year-old woman
presenting with uterine bleeding. Uterine curettage biopsy and uterine discharge cytology revealed SCC. No malignancy was seen in cervical
biopsy. Radical hysterectomy, bilateral salpingo-oophorectomy, omentectomy and lymph node dissection were performed. The endometrial
carcinoma was an infiltrative polypoid tumor composed of non-keratinizing SCC with stratification and intercellular bridges. No
adenocarcinoma element was recognized. The SCC cells were immunohistochemically positive for p53 protein and showed high Ki-67
antigen (labeling, 70%). The SCC was found to invade into the deeper third of the myometrium. No tumor cells were seen in other sites
including the cervix, ovaries, omentum, and lymph nodes. The patients was FIGO stage IC (pT1C, N0, M0), and was treated with radiation and
adjuvant chemotherapy. The patient is now alive without recurrence and metastasis 15 months after the operation. (IJCEP1212005).

Keywords: Endometrium, squamous cell carcinoma, histopathology

Address correspondence to: Dr. Tadashi Terada, Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu-Ku,
Shizuoka 424-8636, Japan. Phone: 81-54-336-1111; Fax: 81-54-336-1315; E-mail: piyo0111jp@yahoo.co.jp