IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 2013;6(3):476-484

Original Article
Study on the clinical significance of Argonaute2 expression in colonic carcinoma by
tissue microarray

Ying-Xin Wang, Xiao-Yan Zhang, Bao-Feng Zhang, Chang-Qing Yang, Heng-Jun Gao

Tongji Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital, Tongji University, Shanghai 200065,China; National
Engineering Center for Biochip at Shanghai 201023, China

Received December 14, 2012; Accepted January 17, 2013; Epub February 15, 2013; Published March 1, 2013

Abstract: Background: To study the expression levels and clinical significance of Argonaute2 (EIF2C2) on colonic carcinomas and normal
tissues. Methods: Colon tissue samples from 90 cases of colonic carcinomas and 90 normal subjects were accumulated and made into a
tissue microarray containing 360 dots. Expression of Argonaute2 (EIF2C2) was detected by immunohistochemical staining of the tissue
microarray. Results: There was significant difference in the expression levels of Argonaute2 (EIF2C2) between colonic carcinomas and normal
tissues (P<0.01). However, the expression of Argonaute2 (EIF2C2) was not related to sex, age, position, differentiation, lymphatic metastasis
and clinical stage of the tumor (P>0.05). Conclusion: Abnormal expression of Argonaute2 (EIF2C2) may be correlated with colon
tumorigenesis. (IJCEP1212020).

Keywords: Tissue mircroarray, immunohistochemstry, colonic carcinoma, Argonaute2

Address correspondence to: Dr. Hengjun Gao, Institute of Digestive Diseases, Tongji Hospital affiliated to Tongji University National
Engineering Center for Biochip at Shanghai, Room 5401, Floor 4, Building 5 No. 151 Libing Rd. Zhangjiang Hi-tech park, Pudong District,
Shanghai, 201203, P.R. China. Phone: 86-21-51320288; Fax: 86-21-51320287; E-mail: hengjun_gao@shbiochip.com