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Int J Clin Exp Pathol 2013;6(5):985-989

Case Report
Primary hepatosplenic CD5-positive diffuse large B-cell lymphoma: a case report with
literature review

Xiaohui Zhang, Manhua Sun, Ling Zhang, Haipeng Shao

Hematopathology and Laboratory Medicine, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, USA;
Department of Pathology, Winter Haven Hospital, Winter Haven, FL, USA

Received January 5, 2013; Accepted March 20, 2013; Epub April 15, 2013; Published May 1, 2013

Abstract: De novo CD5-positive diffuse large B-cell lymphoma (CD5+ DLBCL) accounts for approximately 10% of DLBCL, and is usually
associated with aggressive clinical course. We report a case of CD5+ DLBCL with primary involvement of the spleen and liver, and no distinct
mass lesions or lymphadenopathy. The patient had stage IV disease with bone marrow involvement by lymphoma. The lymphoma cells
showed characteristic portal and intrasinusoidal pattern of infiltrate in the liver. The literature was reviewed and the clinicopathologic features of
7 similar reported cases were summarized. All cases share the common features of hepatosplenomegaly without mass lesions, exclusive red
pulp infiltrate with a diffuse and cordal pattern in the spleen, portal and intrasinusoidal pattern of infiltrate in the liver, and stage IV disease with
poor response to conventional chemotherapy. This may represent a distinct subgroup of CD5+ DLBCL and the diagnosis is important for
prompt clinical treatment. (IJCEP1301010).

Keywords: CD5, diffuse large B-cell lymphoma, hepatosplenomegaly

Address correspondence to: Dr. Haipeng Shao, Hematopathology and Laboratory Medicine, H Lee Moffitt Cancer Center and Research
Institute, 12902 Magnolia Drive, Tampa, FL, USA. Tel: 813-745-2672; Fax: 813-745-1708; E-mail: Haipeng.Shao@moffitt.org