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Int J Clin Exp Pathol 2013;6(4):757-765

Case Report
Anastomosing hemangioma of the kidney: a case report of a rare subtype of
hemangioma mimicking angiosarcoma and review of the literature

Ming Zhao, Changshui Li, Jiangjiang Zheng, Ke Sun

Department of Pathology, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang Province, PR China; Department of Pathology, the First Affi-liated
Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, PR China

Received January 29, 2013; Accepted February 7, 2013; Epub March 15, 2013; Published April 1, 2013

Abstract: Anastomosing hemangioma is a recently described, unusual variant of capillary hemangioma which seems to be unique for the
genitourinary system, with a particular proclivity for the kidney. Histologically, it is characterized by a unique sinusoidal architecture reminiscent
of splenic parenchyma that can lead to concern for angiosarcoma. We herein report a further case of anastomosing hemangioma originating in
the right kidney of a 48-year-old Chinese man. The patient had a past medical history significant for hepatocellular carcinoma; this tumor was
incidentally identified as an asymptomatic right renal mass during the periodical surveillance of the hepatic cancer. The resected tumor
measured 2.5cm in maximum diameter and microscopically demonstrated an overall lobulated growth pattern with alternating cellular areas
composed of anastomosing sinusoidal capillary-sized vessels lined by hobnail endothelial cells, and edematous, hyaline paucicellular areas.
Cytologically the tumor cells were generally bland and exhibited positivity for CD31, CD34 immunohistochemically. The patient had been in a
good status without evidence of tumor recurrence 12 months after the surgery. This rare variant renal hemangioma is in need of more
recognition and should not be over-diagnosed as a malignance, particularly angiosarcoma. (IJCEP1301059).

Keywords: Anastomosing hemangioma, kidney, vascular lesions

Address correspondence to: Dr. Ming Zhao, Department of Pathology, Ningbo Yinzhou Second Hospital, No.1 North Qianhe Road, Yinzhou
District, 315100 Ningbo, Zhejiang Province, PR China. Tel: +86-574-83039018; Fax: +86-574-83038515; E-mail: 552527563@qq.com