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Int J Clin Exp Pathol 2013;6(4):718-723

Original Article
The effect of accompanying dominant follicle development/ovulation on the outcomes of
frozen-thawed blastocyst transfer in HRT cycle

Xuezhou Yang, Xiyuan Dong, Kai Huang, Lan Wang, Ting Xiong, Licheng Ji, Hanwang Zhang

Reproductive Medicine center, Tongji Hospital, Tongji Medicine college, Huazhong University of Science and Techonlogy, Wuhan; Xiangyang
Central Hospital, Xiangyang, Hubei Province, The People’s Republic of China

Received January 31, 2013; Accepted February 26, 2013; Epub March 15, 2013; Published April 1, 2013

Abstract: The artificial regime was widespread used in frozen-thawed embryo transfer (FET). Some researchers asserted that if dominant
follicles developed or ovulation occurred in hormone replacement FET cycles, this cycle should be cancelled because the fitting timing of
transfer was hard to determine. In this study, we compared the difference between the outcome of frozen-thawed blastula transfer in hormone
replacement treatment cycle (HRT) with or without dominant follicle development/ovulation. A total of 171 cases of frozen-thawed blastula
transferred successfully in HRT cycle were retrospectively analyzed. Patients were divided into three groups according to dominant follicle
development, ovulation or not: Group A, cycles without dominant follicle developing. Group B, cycles with dominant follicle developing but
without ovulation. Group C, ovulated cycles. The results showed that there was no significant difference in the pregnancy rates or other
parameters among the three groups, but the abortion rate was higher in group C than those of other two groups. To conclude, dominant follicle
development/ovulation was not the necessary indication to cancel transfer cycles in HRT cycles, and our cautious decision would save many
valuable cycles. (IJCEP1301065).

Keywords: HRT, frozen-thawed blastocyst transferred, dominant follicles, ovulation, pregnancy rates

Address correspondence to: Dr. Hanwang Zhang, Reproductive Medicine center, Tongji Hospital, Tongji Medicine college, Huazhong
University of Science and Techonlogy, Wuhan, 430030, The People’s Republic of China. Tel: 18986132218; E-mail: hanwangzhang@yahoo.
com.cn