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Int J Clin Exp Pathol 2013;6(5):853-861

Original Article
Galectin-3: a novel protein in cerebellar hemangioblastoma

Suhail Al-Salam, Mohammed Al-Salam, Moueid Al Ashari

Department of Pathology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, PO box 17666, UAE; Department of
Surgery, College of Medicine, Al- Mustansiriya University, Baghdad, Iraq; Department of Pathology, Tawam Hospital in Affiliation with Johns
Hopkins International Medicine, Al Ain, UAE

Received February 14, 2013; Accepted March 18, 2013; Epub April 15, 2013; Published May 1, 2013

Abstract: Hemangioblastoma (HB), a rare neoplasm of uncertain histogenesis, is characterized histologically by the presence of vacuolated;
lipid-containing cells ‘stromal cells’ and a well developed, fine capillary network. Stromal cells are the neoplastic component of this tumor. Five-
um sections were stained using streptavidin- biotin immunoperoxidase and immunofluorescent techniques. The stromal cells were uniformly
‘‘HIF-1α, Galectin-3, VEGF, VEGFR, WT-1, and bcl2,’’ positive. Endothelial cells but not stromal cells were uniformly immunoreactive to CD31.
Co-localization of HIF-1α with galectin-3 and VEGF as well as galectin-3 with VEGF in stromal cells is confirmed by immunofluorescent
technique. In conclusion, the development of HB is multi-factorial and the expression of galectin-3 correlates with the expression of HIF-1α and
VEGF. Galectin-3 can be used as a marker for the diagnosis of HB as well as it can be a valuable candidate for future targeting immunotherapy.

Keywords: CNS neoplasms, hemangioblastoma, HIF, galectin-3

Address correspondence to: Dr. Suhail Al-Salam, Department of Pathology, Faculty of medicine and health Sciences, United Arab Emirates
University, Al Ain, UAE. Tel: 0097137672000 Ext-464; Fax: 0097137671966; E-mail: suhaila@uaeu.ac.ae