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Int J Clin Exp Pathol 2013;6(5):911-916

Original Article
Overexpression of IL-9 receptor in diffuse large B-cell lymphoma

Xiao Lv, Lili Feng, Xiaosheng Fang, Yujie Jiang, Xin Wang

Department of Hematology, Provincial Hospital affiliated to Shandong University, China; Institute of Diagnostics, Shandong University, China
Received February 21, 2013; Accepted March 19, 2013; Epub April 15, 2013; Published May 1, 2013

Abstract: Interleukin-9 (IL-9) is initially described as a growth factor secreted by helper T cells. It acts on a variety of immune cells via its
receptor (IL-9R). Recently, the oncogenic activities of IL-9 and IL-9R were reported in some lymphomas but not diffuse large B-cell lymphoma
(DLBCL). The purpose of the present study is to investigate the expression of IL-9R in pathological tissues from patients with DLBCL and to
evaluate its correlation with clinical characteristics. Tissue samples from patients with DLBCL and reactive lymphoid hyperplasia were
analyzed using RT-PCR, western blot and immunohistochemical staining. There was a higher expression of IL-9R within DLBCL tissues
compared with hyperplasic lymph nodes. Immunohistochemical analysis indicated membrane localization of IL-9R in 22 of 36 (61.1%) DLBCL
cases. The upregulated IL-9R was correlated to the serum levels of β2 microglobulin and albumin, International Prognostic Index (IPI) score as
well as Ki-67 expression within tumor tissues. Our findings suggest that overexpression of IL-9R may contribute to the pathogenesis of DLBCL
and is associated with some adverse prognostic parameters. (IJCEP1302031).

Keywords: IL-9 receptor, diffuse large B-cell lymphoma, prognosis

Address correspondence to: Dr. Xin Wang, Provincial Hospital affiliated to Shandong University, No. 324, Jingwu Road, Jinan, Shandong,
250021, China. Tel: 0086-0531-85186358 (B); 0086-13156012606 (M); Fax: 0086-0531-87068707 (B);  E-mail: xinwang55@yahoo.com.cn