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Int J Clin Exp Pathol 2013;6(7):1343-1350
Original Article
Role of angiogenesis in endometrial repair of patients with severe intrauterine adhesion
Yuqing Chen, Yajie Chang, Shuzhong Yao
Department of Obstetrics and Gynecology, First Hospital, Sun Yat-sen University, Guangzhou, China; Department of Obstetrics and Gynecology,
Sixth Hospital, Sun Yat-sen University, Guangzhou, China
Received March 28, 2013; Accepted May 1, 2013; Epub June 15, 2013; Published July 1, 2013
Abstract: Objective: To detect vascular endothelial growth factor (VEGF) expression and micro-vessel density (MVD) in patients with severe
intrauterine adhesion before and after therapy, and to preliminarily explore the role of angiogenesis in the therapy of severe intrauterine
adhesion. Methods: A total of 36 patients with severe intrauterine adhesion were prospectively recruited into the treatment group. In the control
group, 20 patients with normal uterine were recruited. Patients with severe intrauterine adhesion received transcervical resection of adhesions
under hysteroscope and then received artificial hormone therapy for 3 months. Methods: The changes in the organelles of endometrial cells
were evaluated under an electric microscope; Immunohistochemistry was done to detect the VEGF expression and MVD in patients with severe
intrauterine adhesion, which was compared with that in the control group; VEGF expression and MVD were compared among patients with
different prognoses. Results: Electric microscopy showed vascular closure and hypoxic changes in the endometrial tissues of patients with
intrauterine adhesion. After treatment, angiogenesis was observed, and the hypoxic changes in the endometrial glands and interstitium were
also improved. Moreover, the VEGF expression and score of MVD also increased significantly when compared with those before treatment and
in the control group. The VEGF expression and MVD score in intrauterine adhesion patients recovering from treatment were significantly higher
than those in patients non-responding to treatment. Conclusion: In patients with intrauterine adhesion, the endometrial tissues present with
vascular closure, and angiogenesis will be present in the endometrial tissues after treatment. The angiogenesis in the endometrial tissues
may affect the endometrial repair. (IJCEP1303055).
Keywords: Intrauterine adhesion, angiogenesis, vascular endothelial growth factor, micro-vessel density
Address correspondence to: Yuqing Chen, Department of Obstetrics and Gynecology, First Hospital, Sun Yat-sen University, Guangzhou,
China. E-mail: chyqing@mail.sysu.edu.cn; Shuzhong Yao, Department of Obstetrics and Gynecology, First Hospital, Sun Yat-sen University,
Guangzhou, China. E-mail: yszlfy@163.com
Original Article
Role of angiogenesis in endometrial repair of patients with severe intrauterine adhesion
Yuqing Chen, Yajie Chang, Shuzhong Yao
Department of Obstetrics and Gynecology, First Hospital, Sun Yat-sen University, Guangzhou, China; Department of Obstetrics and Gynecology,
Sixth Hospital, Sun Yat-sen University, Guangzhou, China
Received March 28, 2013; Accepted May 1, 2013; Epub June 15, 2013; Published July 1, 2013
Abstract: Objective: To detect vascular endothelial growth factor (VEGF) expression and micro-vessel density (MVD) in patients with severe
intrauterine adhesion before and after therapy, and to preliminarily explore the role of angiogenesis in the therapy of severe intrauterine
adhesion. Methods: A total of 36 patients with severe intrauterine adhesion were prospectively recruited into the treatment group. In the control
group, 20 patients with normal uterine were recruited. Patients with severe intrauterine adhesion received transcervical resection of adhesions
under hysteroscope and then received artificial hormone therapy for 3 months. Methods: The changes in the organelles of endometrial cells
were evaluated under an electric microscope; Immunohistochemistry was done to detect the VEGF expression and MVD in patients with severe
intrauterine adhesion, which was compared with that in the control group; VEGF expression and MVD were compared among patients with
different prognoses. Results: Electric microscopy showed vascular closure and hypoxic changes in the endometrial tissues of patients with
intrauterine adhesion. After treatment, angiogenesis was observed, and the hypoxic changes in the endometrial glands and interstitium were
also improved. Moreover, the VEGF expression and score of MVD also increased significantly when compared with those before treatment and
in the control group. The VEGF expression and MVD score in intrauterine adhesion patients recovering from treatment were significantly higher
than those in patients non-responding to treatment. Conclusion: In patients with intrauterine adhesion, the endometrial tissues present with
vascular closure, and angiogenesis will be present in the endometrial tissues after treatment. The angiogenesis in the endometrial tissues
may affect the endometrial repair. (IJCEP1303055).
Keywords: Intrauterine adhesion, angiogenesis, vascular endothelial growth factor, micro-vessel density
Address correspondence to: Yuqing Chen, Department of Obstetrics and Gynecology, First Hospital, Sun Yat-sen University, Guangzhou,
China. E-mail: chyqing@mail.sysu.edu.cn; Shuzhong Yao, Department of Obstetrics and Gynecology, First Hospital, Sun Yat-sen University,
Guangzhou, China. E-mail: yszlfy@163.com
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