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Int J Clin Exp Pathol 2013;6(7):1261-1271

Original Article
Delayed but not loss of gliogenesis in Rbpj-deficient trigeminal ganglion

Ze-Lan Hu, Xin Zhang, Ming Shi, Zhi-Wen Tian, Ying Huang, Jia-Yin Chen, Yu-Qiang Ding

Shanghai Key Laboratory of New Drug Design, School of Pharmacy, the Shanghai Committee of Science and Technology, East China
University of Science and Technology, Shanghai, 200237, China; Department of Neurology, Xijin Hospital, Fourth Military Medical University, Xi’
an, 710032, China; Key Laboratory of Arrhythmias, Ministry of Education, East Hospital, Shanghai 200092, China; Department of Anatomy and
Neurobiology, Tongji University School of Medicine, Shanghai 200092, China

Received March 28, 2013; Accepted May 22, 2013; Epub June 15, 2013; Published July 1, 2013

Abstract: Somatosensory ganglia including dorsal root ganglion (DRG) and trigeminal ganglion (TG) are derived from a common pool of
neural crest stem cells (NCCs), and are good systems to study the mechanisms of neurogenesis and gliogenesis. Previous studies have
reported that deletion of Rbpj, a critical integrator of activation signals from all Notch receptors, in NCCs and their derived cells resulted in the
delayed gliogenesis at early stage and a loss of glial cells at later stage in the DRG. But the phenotypes in the TG have not been described.
Here we reported although the gliogenesis was also delayed initially in Rbpj-deficient TG, it was recovered as the development progressed, as
shown by the presence of large number of glial cells in the TG at later stages. However, neuronal reduction was observed in Rbpj-deficient TG,
which is similar to what observed in Rbpj-deficient DRG. Taken together, our data indicate the function of Rbpj is diversified and context
dependent in the gliogenesis of somatosensory ganglia. (IJCEP1303056).

Keywords: Dorsal root ganglion, trigeminal ganglion, Rbpj, gliogenesis

Address correspondence to: Dr. Ze-Lan Hu, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of
Science and Technology, 130 Meilong Road, Shanghai, 200237, P.R. China. Tel: 0086-21-64250608; Fax: 0086-21-64250608; E-mail:
Huzelan@hotmail.com; Dr. Yu-Qiang Ding, Department of Anatomy and Neurobiology, Tongji University School of Medicine, 1239 Siping Road,
Shanghai 200092, P.R. China. E-mail: dingyuqiang@gmail.com