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Int J Clin Exp Pathol 2013;6(6):1121-1127

Original Article
Phosphorylated c-Src is a novel predictor for recurrence in cervical squamous cell
cancer patients

Teng Hou, Juan Xiao, Huiting Zhang, Haifeng Gu, Yanling Feng, Jundong Li

State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, GD 510060, China. Equal contributors.
Received April 8, 2013; Accepted April 19, 2013; Epub May 15, 2013; Published June 1, 2013

Abstract: Aims: The molecular mechanisms of the tumorigenesis and recurrence of cervical cancer are poorly understood. The objective of
this study was to analyze the expression of phosphorylated c-Src (phospho-c-Src) and its clinical significance in human cervical cancer.
Methods: The expression of phospho-c-Src was determined by immunohistochemistry in a total of 127 cervical specimens including 20 normal
cervix tissues, 20 cases of carcinoma in situ of cervix (CIS), and 87 cases of cervical squamous cell carcinoma (CSCC). Results: The
expression of phospho-Src in normal cervix, CIS, and CSCC increased gradually in ascending order (p=0.026). In addition, the expression of
phospho-Src was correlated with overall (p=0.037) and recurrence (p=0.001) survival of cervical cancer. In multivariate Cox regression analysis,
phospho-Src expression was an independent prognosis factor for recurrence-free survival (p=0.004). Conclusion: Our present study suggests
that Src signaling may play essential role in cervical cancer progression. Phospho-Src expression may be considered as a prognostic marker
to predict recurrence in CSCC. (IJCEP1304011).

Keywords: Phospho-Src, cervical squamous cell carcinoma, prognosis, recurrence

Address correspondence to: Dr. Jundong Li, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center,
Guangzhou, GD 510060, China. Tel: 0086-1871-8908-165; Fax: 8600-20-8734-3014; E-mail: lijd@sysucc.org.cn; 1aiyan@163.com