|IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 2013;6(6):1121-1127
Phosphorylated c-Src is a novel predictor for recurrence in cervical squamous cell
Teng Hou, Juan Xiao, Huiting Zhang, Haifeng Gu, Yanling Feng, Jundong Li
State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, GD 510060, China. Equal contributors.
Received April 8, 2013; Accepted April 19, 2013; Epub May 15, 2013; Published June 1, 2013
Abstract: Aims: The molecular mechanisms of the tumorigenesis and recurrence of cervical cancer are poorly understood. The objective of
this study was to analyze the expression of phosphorylated c-Src (phospho-c-Src) and its clinical significance in human cervical cancer.
Methods: The expression of phospho-c-Src was determined by immunohistochemistry in a total of 127 cervical specimens including 20 normal
cervix tissues, 20 cases of carcinoma in situ of cervix (CIS), and 87 cases of cervical squamous cell carcinoma (CSCC). Results: The
expression of phospho-Src in normal cervix, CIS, and CSCC increased gradually in ascending order (p=0.026). In addition, the expression of
phospho-Src was correlated with overall (p=0.037) and recurrence (p=0.001) survival of cervical cancer. In multivariate Cox regression analysis,
phospho-Src expression was an independent prognosis factor for recurrence-free survival (p=0.004). Conclusion: Our present study suggests
that Src signaling may play essential role in cervical cancer progression. Phospho-Src expression may be considered as a prognostic marker
to predict recurrence in CSCC. (IJCEP1304011).
Keywords: Phospho-Src, cervical squamous cell carcinoma, prognosis, recurrence
Address correspondence to: Dr. Jundong Li, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center,
Guangzhou, GD 510060, China. Tel: 0086-1871-8908-165; Fax: 8600-20-8734-3014; E-mail: firstname.lastname@example.org; email@example.com