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Int J Clin Exp Pathol 2013;6(7):1327-1336

Original Article
Effects of human bone marrow mesenchymal stem cells on burn injury healing in a
mouse model

Liang Xue, Ying-Bin Xu, Ju-Lin Xie, Jin-Ming Tang, Bin Shu, Lei Chen, Shao-Hai Qi, Xu-Sheng Liu

Department of Burns, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong, P. R. China

Received April 23, 2013; Accepted May 21, 2013; Epub June 15, 2013; Published July 1, 2013

Abstract: Objective: To investigate the feasibility and safety of human bone marrow mesenchymal stem cells (BM-MSCs) transplantation on the
improvement of burn wound healing. Method: Human BM-MSCs were injected into the skin of the mouse models, and the new blood vessels
growth, the engraftment of BM-MSCs and the speed of healing were observed. Moreover the body weight and activity were tested after BM-MSCs
transplantation. Results: We found that wound surface healing was significantly accelerated when BM-MSCs were applied to the wound
surface in mice. Moreover, both the number and density of new blood vessels were increased in the BM-MSC-treated group. The engraftment of
BM-MSCs was also investigated using GFP-labeled cells and no GFP-positive cells were observed in tissues other than the location of
BM-MSC injection. We also found that both body weight and activity were quickly restored in BM-MSC-treated mice, and no tumor growth was
found. Conclusion: The present results suggest that BM-MSC transplantation can effectively improve wound healing in a mouse model of burn
injuries. Use of BM-MSCs might therefore facilitate development and improvement of burn injury treatments in future. (IJCEP1304031).

Keywords: Bone marrow mesenchymal stem cells, burn injury, wound healing, mouse model

Address correspondence to: Dr. Xu-Sheng Liu, Department of Burns, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou,
510080, Guangdong, P. R. China. Phone: +86-20-81122388; E-mail: liuxusheng7984@126.com